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Oklahoma State University
Center for Veterinary Health Sciences

Healthy Animals - Healthy People

Histoplasmosis Treatment Monitoring Study


Histoplasmosis is a common and life-threatening fungal infection that affects pet dogs and cats in Oklahoma and surrounding states.  It is costly to treat and one of the main challenges is determining when to discontinue treatment. If the duration of treatment is too short, the disease if more likely to return; if the duration of treatment is too long, drug adverse-effects are more likely and a considerable amount of money can be wasted.  While there are multiple indicators used to help determine when treatment can be discontinued, none are perfect. In addition, little is known about some indicators, such as repeat tissue sampling to look for fungal organisms. 

This study will investigate the changes to fungal cells, collected via minimally invasive sampling during treatment, and will provide important information to help guide veterinarians when treating this disease in dogs and cats. There are financial incentives for participation in this clinical study.

Eligible Candidates

Any dog or cat that has suspected or confirmed histoplasmosis is a candidate. Histoplasmosis can affect any organ and common clinical signs include weight loss, decreased activity, fever, difficulty breathing, swollen spleen and lymph nodes, diarrhea, skin lesions and joint pain, and swelling. Your veterinarian might be suspicious of histoplasmosis based on clinical signs, physical examination findings or the results of routine diagnostic tests.


For more information or to refer a patient for evaluation and possible inclusion in this clinical study, please contact Dr. Andrew Hanzlicek at the Veterinary Medical Hospital  at 405-744-7000.