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Oklahoma State University
Center For Veterinary Health Sciences

Healthy Animals - Healthy People

Neurotoxicology Laboratory

The above video shows an Interdisciplinary project to develop a nano-scavenger.

Research Areas

  • Age-related sensitivity to pesticides
  • Neuromodulation
  • Endocannabinoid signaling in neurotoxicity
  • Nanoscavengers against OP intoxication
  • Non-cholinesterase targets of anticholinesterases
  • Modulation of neurotoxicity by diet

Affiliations

Society of Toxicology

International Neurotoxicology Association

Current Projects

Nanocarrier-mediated Targeting of Bioscavengers to the Red Blood Cell for Prolonged Circulation and Protection, Defense Threat Reduction Agency, HDTRA1-13-1-0021, 8/2013-8/2017.

Recent Publications

Flynn NH, Topal ÇÖ, Hikkaduwa Koralege RS, Hartson S, Ranjan A, Liu J, Pope C, Ramsey JD (2016). Effect of Cationic Grafted Copolymer Structure on the Encapsulation of Bovine Serum Albumin. Materials Science and Engineering (in press).


K. Sahoo, R.S. Hikkaduwa Koralage, N. Flynn, S. Koteeswara, P. Clark, S. Hartson, J. Liu, J.D. Ramsey, C. Pope, A. Ranjan (2016). Nanoparticle targeting to erythrocyte via the glycophorin A affinity ligand, ERY1 enhances binding without impacting cellular function. Nanomedicine: Nanotechnology, Biology and Medicine, DOI 10.1007/s11095-016-1864-x.


Pope C, Uchea C, Flynn N, Poindexter K, Geng L, Brimijoin WS, Hartson S, Ranjan A,  Ramsey JD, Liu J (2015). In vitro Characterization of Cationic Copolymer-Complexed Recombinant Human Butyrylcholinesterase. Biochem Pharmacol 98: 531-539. 


Liu J, Parsons LH, Pope CN. (2015). Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.  NeuroToxicology 50:20-27.


Quandt, S.A., Pope, C.N., Chen, H., Summers, P. and Arcury, T.A. (2015). Longitudinal assessment of blood cholinesterase activities over two consecutive years among Latino non-farmworkers and pesticide-exposed farmworkers in North Carolina. J Occup Environ Med. 57:851-7.


Liu, J., Pope, C. (2015). The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. NeuroToxicology 46: 12-18.


Liu, J., Parsons, L., Pope, C.N. (2013). Comparative effects of parathion and chlorpyrifos on hippocampal extracellular endocannabinoid levels: influence on cholinergic toxicity. Toxicol. Appl. Pharmacol. 272: 608-615.

Members

Dr. Carey Pope, PI

Kirstin Poindexter, Ph.D. student - Veterinary Biomedical Sciences

Tim Anderson, MS student - Zoology

Gil Repa, Freshman Research Scholar