Skip Navigation
Oklahoma State University
Center for Veterinary Health Sciences

Healthy Animals - Healthy People

Neurotoxicology Lab

Dr. Carey Pope, PI
Dr. Jing Liu Pope, Co-PI

The above video shows an Interdisciplinary project to develop a nano-scavenger.

Research Areas

Age-related sensitivity to pesticides
Neuromodulation
Endocannabinoid signaling in neurotoxicity
Nanoscavengers against OP intoxication
Non-cholinesterase targets of anticholinesterases
Modulation of neurotoxicity by diet

Affiliations

Society of Toxicology
International Neurotoxicology Association
 

Recent Publications

Flynn NH, Topal ÇÖ, Hikkaduwa Koralege RS, Hartson S, Ranjan A, Liu J, Pope C, Ramsey JD (2016). Effect of Cationic Grafted Copolymer Structure on the Encapsulation of Bovine Serum Albumin. Materials Science and Engineering (in press).

K. Sahoo, R.S. Hikkaduwa Koralage, N. Flynn, S. Koteeswara, P. Clark, S. Hartson, J. Liu, J.D. Ramsey, C. Pope, A. Ranjan (2016). Nanoparticle targeting to erythrocyte via the glycophorin A affinity ligand, ERY1 enhances binding without impacting cellular function. Nanomedicine: Nanotechnology, Biology and Medicine, DOI 10.1007/s11095-016-1864-x.

Pope C, Uchea C, Flynn N, Poindexter K, Geng L, Brimijoin WS, Hartson S, Ranjan A,  Ramsey JD, Liu J (2015). In vitro Characterization of Cationic Copolymer-Complexed Recombinant Human Butyrylcholinesterase. Biochem Pharmacol 98: 531-539. 

Liu J, Parsons LH, Pope CN. (2015). Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.  NeuroToxicology 50:20-27.

Quandt, S.A., Pope, C.N., Chen, H., Summers, P. and Arcury, T.A. (2015). Longitudinal assessment of blood cholinesterase activities over two consecutive years among Latino non-farmworkers and pesticide-exposed farmworkers in North Carolina. J Occup Environ Med. 57:851-7.

Liu, J., Pope, C. (2015). The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. NeuroToxicology 46: 12-18.

Liu, J., Parsons, L., Pope, C.N. (2013). Comparative effects of parathion and chlorpyrifos on hippocampal extracellular endocannabinoid levels: influence on cholinergic toxicity. Toxicol. Appl. Pharmacol. 272: 608-615.

Current Projects

Nanocarrier-mediated Targeting of Bioscavengers to the Red Blood Cell for Prolonged Circulation and Protection, Defense Threat Reduction Agency, HDTRA1-13-1-0021, 8/2013-8/2017.


Members

Kirstin Poindexter
PhD student - Veterinary Biomedical Sciences

Tim Anderson
MS student - Zoology

Gil Repa
Freshman Research Scholar